Activity of combinations of effective drugs against M. leprae in the nude mice

Title:
Activity of combinations of effective drugs against M. leprae in the nude mice

Author:
Wang H, Shi M, Wang H

Address:
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, 12 Jiangwangmiao Road, Nanjing 210042, P. R. China

Source:
Chinese Journal of Dermatology 1996, 29(1):25-26

Abstract:
OBJECTIVES: In order to improve multi-drug treatment (MDT) regiment for leprosy patients, we studied the activity of the combination of several new bactericidal drugs against M. leprae in the nude mice. METHODS: M. leprae-infected nude mice were treated from day 84 to 179 after inoculation using kinetic method. We evaluated three regiments: minocycline (M) 0.01%+dapsone (D) 0.001%; M+D+ofloxacin(O) 0.05%; M + D +refampicin (R) 0.01%in diet. RESULTS: The results indicated that there were additive or synergistic activity against M. leprae, furthermore, combination of three effective drugs were confirm-ed to be superior to that of two drugs. CONCLUSIONS: Bactericidal activity of M+D+R was the best in these regiments, 5 months after stopping therapy, no multiplication of M. leprae were observed in both hind foot pads of inoculated nude mice.

Key words: M. leprae Nude mice Multi-drug treatment

Language: Chinese