Histopathological study on experimental leprosy
in tupaias (tupaia belangeri yunalis)
Title:
Histopathological study on experimental leprosy in tupaias
(tupaia belangeri yunalis)
Author:
Wang H, Liu J, Yu L, et al.
Address:
National Center for STD and Leprosy Control, Institute
of Dermatology, Chinese Academy of Medical Sciences, 12
Jiangwangmiao Road, Nanjing 210042, P. R. China
Source:
Chin J Dermatal, Aug 1996, 29 (4): 258-260
Abstract:
OBJECTIVES: In order to explore new experimental
leprosy in tupaias. METHODS: Ten tupaias
were infected with 5.0กม104-2.67กม107 M. leprae by different
routes, intravenous and subcutaneous (fore and hind foot
pads, nose, ears) or intratesticular inoculation. RESULTS:
These animals were scarificed 373-786 days after infection
, the average time were 546 days. Large patches of leprous
granulomatous infiltration, containing a large number
of acid fast bacilli (AFB) were found at the inoculated
sites by histopathological examination. The morphologic
indices (MI) of most AFB were greater than 40%, and the
bacterial indices(BI) ranged 5+~6+. The dermal nerves
showed "onion skin-like" appearance and were
severely destroted with large numbers of AFB and globi.
It looks like borderline lepromatous leprosy in tissue
sections. The bacilli in the foot pads of tupaia increased
up to 5.97กม109/g of tissue. CONCLUSIONS:
According to the histopathological observation and bacteriological
determination, it is proved that experimental leprosy
model in tupaia has been established.
Key words: Leprosy Mycobacterium leprae
Tupaiidae
Language: Chinese
