Study on minimum effective dosages of rifampin against
21 strains of M. leprae
Title:
Study on minimum effective dosages of rifampin against
21 strains of M. leprae
Author:
Wang H, Zhang W, Yu L, et al
Address:
National Center for STD and Leprosy Control, Institute
of Dermatology, Chinese Academy of Medical Sciences, 12
Jiangwangmiao Road, Nanjing 210042, P. R. China
Source:
Chin J Dermatol,1999,32(1):51-52
Abstract:
OBJECTIVE: IN order to study on minimum
effective dosages(MED) of rifampin (RFP) against M. leprae.
METHODS: In this paper, we detected the
MED of 21 strains of mycobacterium leprae to RFP by the
mouse footpad technique. RESULTS: The
results showed that the MED of 13 strains administered
the RFP diet was 0.001%~¡Ü0.0001%, 8 of them were ¡Ü0.0001-0.0003%.
The MED of 8 strains treated RFP using the gavage method
was 2.5-5.0mg/Kg, 5 of them was 2.5mg/Kg.Among above-mentioned
13 strains, 5 were also treated by gavage in the meantime
for comparison. When the dosage was <10mg/Kg, it has
bacteriostatic effect on bacilli .The results also indicated
that, the MED of domestic strains to RFP may be lower
than that of abroad. CONCLUSION: The
authors suggested that the dosage which was below 10mg/Kg
should be set up , in order to found the lower degree
RFP-resistant strains . In addition, the results must
be made a concrete analysis and then the diagnosis of
a drug-resistant strain would be decided. The determination
of the RFP concentration in the sera of mice consists
with that of abroad.
Key Words: RFP M. leprae Drug-resistant
Language: Chinese
